Each tablet size is packaged in blister packs containing 4 tablets per perforated sheet. There were 8 dogs (4 males and 4 females) in the 2 mg/kg group and 16 dogs (8 males and 8 females) in all other groups.
However, it remains the responsibility of the readers to familiarize themselves with the product information contained on the Canadian product label or package insert. The empirical formula is C32H40N2O C6H8O7 H2O and the molecular weight 678.81. Dogs used in the study were weaned early, minimally acclimated to the test facility, and many of the dogs in the study tested positive for coccidia.
● Maropitant is a highly protein bound drug; use caution when administering other drugs that are highly protein bound. The following adverse events are based on post-approval adverse drug experience reporting.
This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment.
Hypocellular femoral bone marrow described as “minimal” was seen in 1 male that received 1 mg/kg maropitant SC for 5 days; reticulocyte counts were not available for this dog. Subscribe to Drugs.com newsletters for the latest medication news, alerts, new drug approvals and more. Hypocellular femoral bone marrow described as “minimal” was seen in 1 male that received 1 mg/kg maropitant SC for 5 days; reticulocyte counts were not available for this dog. Maropitant is a neurokinin 1 (NK1) receptor antagonist which acts by inhibiting the binding of substance P, a neuropeptide of the tachykinin family.
Following administration of apomorphine (central emetic stimuli), vomiting was observed in 33% (4 of 12) of Beagle dogs treated with Cerenia Tablets and 100% (12 of 12) of Beagle dogs treated with placebo tablets. There were no notable differences in mean laboratory values between CERENIA-treated and placebo-treated patients.
Administration for the prevention of motion sickness may be repeated daily for a maximum of 2 consecutive days. Dogs should be carefully observed following administration to ensure that the tablet(s) is swallowed.
The observed drug accumulation ratios were 2.46 and 4.81, after oral administration of 2 and 8 mg/kg, respectively. In puppies 16 weeks and older, bone marrow hypoplasia was not seen (See Animal Safety Section). We comply with the HONcode standard for trustworthy health information -, Warnings and cautions for Cerenia Tablets, Direction and dosage information for Cerenia Tablets. Symptomatic treatment of acute vomiting: In a study of 275 canine patients presented to veterinary hospitals with a history of acute vomiting, dogs were initially administered CERENIA injection or placebo on Day 0. Dogs may have experienced more than one of the observed adverse reactions. Forty Beagle dogs (20 males and 20 females) between 16 - 18 weeks of age were administered CERENIA Tablets orally once daily for 6 days at 0, 8 and 24 mg/kg. For Prevention of Acute Vomiting in dogs 7 months of age and older:Administer CERENIA Tablets orally at a minimum dose of 2 mg/kg (0.9 mg/lb) body weight once daily until resolution of acute vomiting.
Interpretation of these results is complicated by the health status of study animals. Fifty six Beagle dogs (28 males and 28 females) approximately 16 weeks of age were administered CERENIA Tablets orally once daily for 15 days at 0, 2, 6, and 10 mg/kg. Every effort has been made to ensure the accuracy of the Cerenia Tablets (16 mg) information published above. CERENIA causes dose related decreases in appetite and body weight (see ANIMAL SAFETY). The chemical structure of maropitant citrate is: Cerenia (maropitant citrate) Tablets are indicated for the prevention of acute vomiting and the prevention of vomiting due to motion sickness in dogs.
In puppies 16 weeks and older, bone marrow hypocellularity was not observed (see ANIMAL SAFETY). Of the 199 dogs included in the analysis for effectiveness, 27 of 54 dogs (50%) in the placebo group displayed vomiting at some time during the study and 31 of 145 dogs (21.4%) in the treated group displayed vomiting during the study period.