Définition, traduction, prononciation, anagramme et synonyme sur le dictionnaire libre Wiktionnaire. Diaries should include questions on asthma symptoms, night-waking due to asthma, and reliever use. More work is needed to develop clinical criteria for pediatric asthma exacerbations that can be applied prospectively. Primary care consultations should be expressed as the weighted mean or median rate per patient per year, divided into scheduled and unscheduled consultations. However, again, such associations are generally poor, including those with indices of airway inflammation (167). There is clinical utility in distinguishing patients with “difficult-to-treat” or severe asthma from those who have “easy-to-treat” or mild asthma. Buhl R, Creemers JPHM, Vondra V, Martelli NA, Naya IP, Ekstrom T. Once-daily budesonide/formoterol in a single inhaler in adults with moderate persistent asthma. The Gaining Optimal Asthma ControL study.
Effect of inhaled formoterol and budesonide on exacerbations of asthma.
The predictive value of exhaled nitric oxide measurements in assessing changes in asthma control. Although the ACT has been translated into more than 40 languages, further research is required to ensure validity in different languages and practice settings. Accuracy of eosinophils and eosinophil cationic protein to predict steroid improvement in asthma. It should be used as a specific assessment tool in asthma clinical trials. For the composite ACQ diary score, a change of 0.5 (scale 0–6, baseline 1.5) was reported as clinically important (111). Due to logistic and cost issues, FeNO is the only biomarker likely to have a role in primary care–based asthma studies, although it is possible that with technological improvements, other techniques including sputum induction could have a role in the medium term. Kavuru M, Melamed J, Gross G, Laforce C, House K, Prillaman B, Baitinger L, Woodring A, Shah T. Salmeterol and fluticasone propionate combined in a new powder inhalation device for the treatment of asthma: a randomized, double-blind, placebo-controlled trial. In the clinical setting, the absolute severity of exacerbations will vary considerably from patient to patient, or over time. The dose–response curve for ICS plateaus at a low dose, and there is little evidence of an additional effect above 200 μg/day (beclomethasone equivalent) in most patients (278, 279).
Passive smoke inhalation decreases exhaled nitric oxide in normal subjects. The influence of salivary contamination on EBC values may be considerable, as many of the mediators assayed are found in high concentration in saliva (329). Muller KC, Jorres RA, Magnussen H, Holz O. ††Airway hyperresponsiveness is a marker of underlying disease activity, and the extent to which this has been modified by treatment. Scores for different symptoms are often combined into mean or cumulative scores, either for day and night separately or as a “total asthma symptom score” (101), but there is little standardization. Fuhlbrigge AL, Adams RJ, Guilbert TW, Grant E, Lozano P, Janson SL, Martinez F, Weiss KB, Weiss ST. FeNO is increased (by about 60%) during the late response to allergen in subjects with atopic asthma (317), and is reduced two- to fourfold by corticosteroids in patients with asthma (279, 318, 319). Reddel HK, Toelle BG, Marks GB, Ware SI, Jenkins CR, Woolcock AJ. Extrapolation of dose–response curves is strongly discouraged. RECOMMENDED OUTCOME MEASURES RELATING TO ASTHMA CONTROL FOR CLINICAL TRIALS: LIST OF MEASURES. Assay of sputum supernatant mediators has made an important contribution to our understanding of the mechanisms of airway disease, but there is no evidence that these measures inform our understanding of asthma control. Children under 12 years of age may have difficulty reading or understanding a questionnaire without assistance. Dose response of inhaled corticosteroids on bronchial hyperresponsiveness: a meta-analysis. (Ex.
The results from different sources may not be identical, particularly as responses by patients are usually based on their recollections rather than on contemporaneous notes (363). Repeatability of bronchial hyperresponsiveness to adenosine-5′-monophosphate (AMP) by a short dosimeter protocol. Subjects should always be asked to complete symptom diaries before measuring PEF, to avoid bias. Impact of inhaled salmeterol/fluticasone propionate combination product versus budesonide on the health-related quality of life of patients with asthma. Berry M, Hargadon B, Morgan A, Shelley M, Richter J, Shaw D, Green RH, Brightling C, Wardlaw AJ, Pavord ID. The AQLQJuniper has been shown to correlate with asthma control questionnaires such as ACQ (158) and ATAQ (226). — (Sankara premier, commentaire sur Côte d’ivoire: Vidéo des microbes en action Adjamé, koaci.com, 28 septembre 2017) Amlan, Mercon ! The intraclass correlation coefficient for repeated measurement of the two-point slope to histamine is only 0.26, but can be improved by calculating the slope by least-square analysis (195). Indeed, improvement in symptoms using, for example, LABA therapy, may occur without any change in pre-bronchodilator FEV1 (61). Before using composite scores, it is important to check copyright restrictions and charges. The minimal important difference (MID) for improvement and worsening in FEV1, based on patient perception of change, is about 10% (110, 156), but this is not well established. Kanengiser S, Dozor AJ. A randomized trial comparing peak expiratory flow and symptom self-management plans for patients with asthma attending a primary care clinic. (Ex : Hô hô, môgô-la pense qu'il peut me daba, quoi ? Buhl R, Hanf G, Soler M, Bensch G, Wolfe J, Everhard F, Champain K, Fox H, Thirlwell J.
Data on national or jurisdictional prices for medical care and pharmaceutical services are required to produce estimates of cost. Kharitonov SA, O'Connor BJ, Evans DJ, Barnes PJ. More work is needed to understand how health economic evaluations can take into account the existing variation in delivery between different countries or regions. It was approved initially by the ERS and later extended to include the American Thoracic Society (ATS), the aim being to provide recommendations about the assessment of asthma in clinical trials and clinical practice. Increased nitric oxide in exhaled air of asthmatic patients. The MID is reported to be 0.5 points (383).
Some studies defined “exacerbation days” either singly (23, 36, 41) or as consecutive days (13), but similar features were used in other studies to identify “poor control days” (16). This site uses cookies. It reflects the increased sensitivity of the airways to inhaled stimuli, a problem reported by the majority of patients with asthma, even when spirometry is normal. 1) Cécé Achi : Ayi, donc c’est vrai vrai quoi ? It is not considered necessary to specify whether LABA or study medication should be withheld, as FEV1 is close to plateau levels after 400 μg albuterol. There is no evidence that different methods result in clinically important differences in success rates or sputum differential cell counts (264, 266). American Thoracic Society. Mortimer KM, Redline S, Kattan M, Wright EC, Kercsmar CM. Although the majority of patients in primary care demonstrate concordance between symptoms and eosinophilic airway inflammation, significant discordance is seen in patients referred for secondary care (288). American Thoracic Society; European Respiratory Society. Is overall asthma control being achieved? Simeoni M-C, Schmidt S, Muehlan H, Debensason D, Bullinger M, Disabkids Group. This suggests that the range and intervals for individual item scores could be improved.